If there was a caesura towards the implementation of the Final Solution through mass murder, it is marked by the German "war of destruction" waged against the Soviet Union from June 22, 1941. Provided with instructions that called for the rapid pacification of conquered areas and that stressed the "sub-human" nature of broad strata of the population as well as the need for drastic measures to fight the deadly threat posed by "Judeo-Bolshevism" to the Nazi grand design, German soldiers, SS-men, and policemen murdered Jews from the first days of the campaign. Regionally different patterns of persecution unfolded until the end of 1941; its most prominent feature – the broadening scope of the killings from male Jews of military age (Heydrich's notorious letter to the higher SS- and Police heads in the occupied Soviet Union dated July 2, 1941, listed "Jews in party and state positions" and "other radical elements" among those to be executed) to women and children – underscores the absence of a central order and the preference of the Berlin authorities for controlled escalation.
The first transcription of Anne's diary was in German, made by Otto Frank for his friends and relatives in Switzerland, who convinced him to send it for publication.[23] The second, a composition of Anne Frank's versions A and B as well as excerpts from her essays became the first draft submitted for publication, with an epilogue written by a family friend explaining the fate of its author. In the spring of 1946, it came to the attention of Dr. Jan Romein and his wife Annie Romein-Verschoor, two Dutch historians. They were so moved by it that Anne Romein made unsuccessful attempts to find a publisher, which led Romein to write an article for the newspaper Het Parool:[24]

In his 1965 essay "Command and Compliance", which originated in his work as an expert witness for the prosecution at the Frankfurt Auschwitz Trials, the German historian Hans Buchheim wrote there was no coercion to murder Jews and others, and all who committed such actions did so out of free will. Buchheim wrote that chances to avoid executing criminal orders "were both more numerous and more real than those concerned are generally prepared to admit",[468] and that he found no evidence that SS men who refused to carry out criminal orders were sent to concentration camps or executed.[469] Moreover, SS rules prohibited acts of gratuitous sadism, as Himmler wished for his men to remain "decent"; acts of sadism were carried out on the initiative of those who were either especially cruel or wished to prove themselves ardent National Socialists.[468] Finally, he argued that those of a non-criminal bent who committed crimes did so because they wished to conform to the values of the group they had joined and were afraid of being branded "weak" by their colleagues if they refused.[470]
From 1933 onward, anti-Jewish propaganda had flooded Germany. Under the skillful direction of Joseph Goebbels, his Nazi Propaganda Ministry churned out a ceaseless stream of leaflets, posters, newspaper articles, cartoons, newsreels, slides, movies, speeches, records, exhibits and radio pronouncements. As a result, the accusations, denunciations and opinions which Hitler first expressed in his book, Mein Kampf, had become institutionalized, accepted as time-tested beliefs by all Nazis, taught as fact to impressionable youths, and drilled into the minds of eager-to-please SS recruits.
Mengele's name was mentioned several times during the Nuremberg trials in the mid-1940s, but the Allied forces believed that he was probably already dead.[79] Irene Mengele and the family in Günzburg also alleged that he had died.[80] Working in West Germany, Nazi hunters Simon Wiesenthal and Hermann Langbein collected information from witnesses about Mengele's wartime activities. In a search of the public records, Langbein discovered Mengele's divorce papers, which listed an address in Buenos Aires. He and Wiesenthal pressured the West German authorities into starting extradition proceedings, and an arrest warrant was drawn up on 5 June 1959.[81][82] Argentina initially refused the extradition request because the fugitive was no longer living at the address given on the documents; by the time extradition was approved on 30 June, Mengele had already fled to Paraguay and was living on a farm near the Argentine border.[83]
This was more than an exaggerated adolescent flourish. She had already intuited what greatness in literature might mean, and she clearly sensed the force of what lay under her hand in the pages of her diary: a conscious literary record of frightened lives in daily peril; an explosive document aimed directly at the future. In her last months, she was assiduously polishing phrases and editing passages with an eye to postwar publication. Het Achterhuis, as she called her manuscript, in Dutch—“the house behind,” often translated as “the secret annex”—was hardly intended to be Anne Frank’s last word; it was conceived as the forerunner work of a professional woman of letters.

When France fell to Nazi Germany, the mission to resist the Nazis became increasingly important. Following the establishment of the Vichy France regime during the occupation, Trocmé and his church members helped their town develop ways of resisting the dominant evil they faced. Together they established first one, and then a number of "safe houses" where Jewish and other refugees seeking to escape the Nazis could hide. Many refugees were helped to escape to Switzerland following an underground railroad network. Between 1940 and 1944 when World War II ended in Europe, it is estimated that about 3500 Jewish refugees including many children were saved by the small village of Le Chambon and the communities on the surrounding plateau because the people refused to give in to what they considered to be the illegitimate legal, military, and police power of the Nazis.

Being a twin, regardless of age, meant survival in 1944. Some 3,000 children (or about 1,500 sets of twins) were selected for the experiments. They were not terrified of him but rather they were often intimidated by some of what he did. They knew of his temper and his passion for his work. Yet, they were also aware of his role in their survival. "Being on Mengele’s list was better than being on no list," said Eva Mozes Kor.
In the eyes of the world, we’re doomed, but if after all this suffering, there are still Jews left, the Jewish people will be held up as an example. Who knows, maybe our religion will teach the world and all the people in it about goodness, and that’s the reason, the only reason, we have to suffer. . . . God has never deserted our people. Through the ages Jews have had to suffer, but through the ages they’ve gone on living, and the centuries of suffering have only made them stronger.

Another Polish courier, Jan Karski, reached the west in November 1942, carrying messages from Jewish leaders in Poland. He had himself witnessed the conditions in the Warsaw ghetto and in what he believed to be the Belzec death camp, and was eager to inform the world. Karski saw the British foreign secretary, Anthony Eden, and US President Roosevelt, but they seemed to be more interested in military intelligence than in atrocity stories. Partly as a result of Karski's mission, however, the Allies agreed to a joint declaration, read to the British Parliament on 17 December, which acknowledged Nazi war crimes and threatened punishment for the perpetrators. Subsequently millions of leaflets were dropped in the course of bombing raids on German cities to inform Germans of the facts, but these had little or no effect.
When an outbreak of noma (a gangrenous bacterial disease of the mouth and face) struck the Romani camp in 1943, Mengele initiated a study to determine the cause of the disease and develop a treatment. He enlisted the assistance of prisoner Dr. Berthold Epstein, a Jewish pediatrician and professor at Prague University. The patients were isolated in a separate barracks and several afflicted children were killed so that their preserved heads and organs could be sent to the SS Medical Academy in Graz and other facilities for study. This research was still ongoing when the Romani camp was liquidated and its remaining occupants killed in 1944.[2]