While Clauberg and Schumann were busy with experiments designed to develop methods for the biological destruction of people regarded by the Nazis as undesirable, another medical criminal, SS-Hauptsturmführer Josef Mengele, M.D., Ph.D., was researching the issues of twins and the physiology and pathology of dwarfism in close cooperation with the Kaiser Wilhelm Institute of Anthropology, Genetics, and Eugenics in Berlin-Dahlem. He was also interested in people with different colored irises (heterochromia iridii), and in the etiology and treatment of the gangrenous disease of the face known as noma Faciei (cancrum oris, gangrenous stomatitis), a little understood disease endemic to the Gypsy prisoners in Auschwitz.
Of particular note, was Hitler's oft-repeated claim that Jews everywhere were engaged in an international conspiracy to achieve world domination. In a speech given on January 30, 1939, commemorating the sixth anniversary of his rule in Germany, Hitler added a stark new warning: "If the international Jewish financiers in and outside Europe should succeed in plunging the nations once more into a world war, then the result will not be the Bolshevizing of the earth, and thus the victory of Jewry, but the annihilation of the Jewish race in Europe!"

Responding to domestic pressures to act on behalf of Jewish refugees, U.S. Pres. Franklin D. Roosevelt convened, but did not attend, the Évian Conference on resettlement, in Évian-les-Bains, France, in July 1938. In his invitation to government leaders, Roosevelt specified that they would not have to change laws or spend government funds; only philanthropic funds would be used for resettlement. Britain was assured that Palestine would not be on the agenda. The result was that little was attempted and less accomplished.
With the invasion of the Soviet Union on June 22 1941, the Nazis launched a crusade against 'Judaeo-Bolshevism', the supposed Jewish-Communist conspiracy. Behind the front lines, four police battalions called Einsatzgruppen (operations groups) moved from town to town in the newly occupied Soviet territories, rounding up Jewish men and suspected Soviet collaborators and shooting them. In subsequent sweeps, making heavy use of local volunteers, the Einsatzgruppen targeted Jewish women and children as well. In total, the Einsaztgruppen murdered some two million people, almost all Jews.
Gentiles whose status placed them on the periphery of a community generally had fewer social constraints and a higher level of independence. This sense of independence, in turn, seems to have made many rescuers more likely to act in accordance with their personal values and moral precepts, even when these standards were in opposition to societal norms. Such rescuers were propelled by values connected to self-approval. In interviews, they insisted again and again that they had to be at peace with themselves, with their ideas of what was right or wrong.
Hitler's first step was to take the Jews civil rights away. then he branded and labeled them as if they were cattle. Then he sent them to death and labor camps. If they were they were sent to ghettos. in 1941 most of the Jewish population in Germany would be sent to camps. Nazis racial policies took over everything to try and find a solution for the Jewish question. the Nazis tried to separate them and force migration but when this did not work they found a final solution to the Jewish question. This was the murdering of the Jews in Europe. No-one knows when this decision was made but when the ghettos were built Heydrich said '' this is one step closer to the final aim''.    
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According to scholars Christian Gerlach and Peter Monteath, among others, the pivotal moment for Hitler’s decision came on December 12, 1941, at a secret meeting with some 50 Nazi officials, including Joseph Goebbels (Nazi minister of propaganda) and Hans Frank (governor of occupied Poland). Though no written documents of the meeting survive, Goebbels described the meeting in his journal on December 13, 1941:

In the manuscript, her original diaries are written over three extant volumes. The first volume (the red-and-white checkered autograph book) covers the period between June 14 and December 5, 1942. Since the second surviving volume (a school exercise book) begins on December 22, 1943, and ends on April 17, 1944, it is assumed that the original volume or volumes between December 1942 and December 1943 were lost - presumably after the arrest, when the hiding place was emptied on Nazi instructions. However, this missing period is covered in the version Anne rewrote for preservation. The third existing volume (which was also a school exercise book) contains entries from April 17 to August 1, 1944, when Anne wrote for the last time before her arrest.[16]:2
Mengele assembled hundreds of pairs of twins and sometimes spent hours measuring various parts of their bodies and taking careful notes. He often injected one twin with mysterious substances and monitored the illness that ensued. He applied painful clamps to children’s limbs to induce gangrene, injected dye into their eyes – which were then shipped back to a pathology lab in Germany – and gave them spinal taps.
^ Jump up to: a b Eberhard Jäckel (Die Zeit, 1986): "Ich behaupte ... daß der nationalsozialistische Mord an den Juden deswegen einzigartig war, weil noch nie zuvor ein Staat mit der Autorität seines verantwortlichen Führers beschlossen und angekündigt hatte, eine bestimmte Menschengruppe einschließlich der Alten, der Frauen, der Kinder und der Säuglinge möglichst restlos zu töten, und diesen Beschluß mit allen nur möglichen staatlichen Machtmitteln in die Tat umsetzte." ("I maintain ... that the National Socialist killing of the Jews was unique in that never before had a state with the authority of its leader decided and announced that a specific group of humans, including the elderly, the women, the children and the infants, would be killed as quickly as possible, and then carried out this resolution using every possible means of state power.")[35]

In 1950, the Dutch translator Rosey E. Pool made a first translation of the Diary, which was never published.[26] At the end of 1950, another translator was found to produce an English-language version. Barbara Mooyaart-Doubleday was contracted by Vallentine Mitchell in England, and by the end of the following year, her translation was submitted, now including the deleted passages at Otto Frank's request. As well, Judith Jones, while working for the publisher Doubleday, read and recommended the Diary, pulling it out of the rejection pile.[27] Jones recalled that she came across Frank's work in a slush pile of material that had been rejected by other publishers; she was struck by a photograph of the girl on the cover of an advance copy of the French edition. "I read it all day", she noted. "When my boss returned, I told him, 'We have to publish this book.' He said, 'What? That book by that kid?'" She brought the diary to the attention of Doubleday's New York office. "I made the book quite important because I was so taken with it, and I felt it would have a real market in America. It's one of those seminal books that will never be forgotten", Jones said.[28] The book appeared in the United States and in the United Kingdom in 1952, becoming a best-seller. The introduction to the English publication was written by Eleanor Roosevelt.

By the late 1930s there was a desperate search for countries of refuge. Those who could obtain visas and qualify under stringent quotas emigrated to the United States. Many went to Palestine, where the small Jewish community was willing to receive refugees. Still others sought refuge in neighbouring European countries. Most countries, however, were unwilling to receive large numbers of refugees.
Another Polish courier, Jan Karski, reached the west in November 1942, carrying messages from Jewish leaders in Poland. He had himself witnessed the conditions in the Warsaw ghetto and in what he believed to be the Belzec death camp, and was eager to inform the world. Karski saw the British foreign secretary, Anthony Eden, and US President Roosevelt, but they seemed to be more interested in military intelligence than in atrocity stories. Partly as a result of Karski's mission, however, the Allies agreed to a joint declaration, read to the British Parliament on 17 December, which acknowledged Nazi war crimes and threatened punishment for the perpetrators. Subsequently millions of leaflets were dropped in the course of bombing raids on German cities to inform Germans of the facts, but these had little or no effect.
The capture, trial and execution in the early 1960s of Adolf Eichmann, the bureaucratic organizer of the Holocaust, led many people to believe that the Mossad would next want to get its hands on Mengele. Many in Israel and around the world figured that the Mossad would have no trouble doing so. But the truth was that for years, the leaders of the government and the agency were simply not all that interested.

In another case in which a mother did not want to be separated from her thirteen-year-old daughter, and bit and scratched the face of the SS man who tried to force her to her assigned line, Mengele drew his gun and shot both the woman and the child. As a blanket punishment, he then sent to the gas all people from that transport who had previously been selected for work, with the comment: "Away with this shit!" (Robert Jay Lifton, The Nazi Doctors.)
When France fell to Nazi Germany, the mission to resist the Nazis became increasingly important. Following the establishment of the Vichy France regime during the occupation, Trocmé and his church members helped their town develop ways of resisting the dominant evil they faced. Together they established first one, and then a number of "safe houses" where Jewish and other refugees seeking to escape the Nazis could hide. Many refugees were helped to escape to Switzerland following an underground railroad network. Between 1940 and 1944 when World War II ended in Europe, it is estimated that about 3500 Jewish refugees including many children were saved by the small village of Le Chambon and the communities on the surrounding plateau because the people refused to give in to what they considered to be the illegitimate legal, military, and police power of the Nazis.

Sources: C.A.N.D.L.E.S; Kor, Eva Mozes. Echoes from Auschwitz. IN.: C.A.N.D.L.E.S. 1995; Lifton, Robert Jay. The Nazi Doctors. The United States: Basic Books. 1986; Nyiszli., Dr. Miklos. Auschwitz: A Doctor's Eyewitness Account. New York: Fawcett Crest. 1960; Posner, Gerald L. and John Ware. Mengele: The Complete Story. New York: Dell Publishing. 1986; Ramati, Alexander. And the Violins Stopped Playing
Eichmann received various levels of cooperation from each of the various occupied governments. But in countries such as Holland, Belgium, Albania, Denmark, Finland and Bulgaria, some Jews were saved from their deaths by the action of the sympathetic populace and government officials. Denmark’s government and populace were exemplary in their heroism in saving Jews. In other countries such as Poland, Greece, France, and Yugoslavia, the deportation of Jews to the death camps was facilitated by the cooperation of the government.

Although Dr. Josef Mengele did not join the staff at Birkenau until May 1943, survivors testified during the Allied war crimes trials that he did selections in 1942. Besides the initial selection when the transport trains arrived at Birkenau, there were later selections of the women in the camp. Dr. Mengele was the chief doctor for the women's barracks, and he would periodically show up to select women for work or the gas chamber. One of the women who survived one of these selections was Sophia Litwinska, a Polish Jewess who was married to an Aryan man.
Not long after beginning the survey of the site, Freund and his team confirmed the existence of a previously unmarked burial pit. At 80 feet across and 15 feet deep, the scientists calculated that the grave contained the cremated remains of as many as 7,000 people. The researchers also released the preliminary results of their search for the tunnel, along with a series of ERT-generated cross sections that revealed the tunnel’s depth beneath the ground’s surface (15 feet at points) and its dimensions: three feet by three feet at the very widest, not much larger than a human torso. From the entrance inside the bunker to the spot in the forest, now long grown over, where the prisoners emerged measured more than 110 feet. At last, there was definitive proof of a story known until now only in obscure testimonies made by a handful of survivors—a kind of scientific witness that transformed “history into reality,” in the words of Miri Regev, Israel’s minister of culture, who highlighted the importance of documenting physical evidence of Nazi atrocities as a bulwark against “the lies of the Holocaust deniers.”
Three SS officers socialize at Auschwitz in 1944. From left to right: Richard Baer (commandant), Dr. Josef Mengele and Rudolf Höss (former commandant). Baer escaped but was captured in 1960; he died in 1963 while awaiting trial. Höss was executed for his crimes in 1947, shortly after receiving the sacrament of penance and Holy Communion as Viaticum. Mengele died while swimming at a seaside resort in 1979, after having lived to see his work at Auschwitz vindicated by the legalization of abortion in the U.S. and elsewhere. (Karl-Friedrich Höcker, public domain, via Yad Vashem and Wikimedia Commons)
For the first time, camps were created specifically for Jews. Their conditions were far worse than other camps. The implicit intention was that the inmates would die there. Increasing numbers of Jews in Poland were relocated in ghettos. Non-Jewish Poles were also deported from their farms and villages to make room for ‘pure’ ethnic Germans to populate the new territory.
Along with several other Auschwitz doctors, Mengele transferred to Gross-Rosen concentration camp in Lower Silesia on 17 January 1945, taking with him two boxes of specimens and the records of his experiments at Auschwitz. Most of the camp medical records had already been destroyed by the SS[57][58] by the time the Red Army liberated Auschwitz on 27 January.[59] Mengele fled Gross-Rosen on 18 February, a week before the Soviets arrived there, and traveled westward to Žatec in Czechoslovakia, disguised as a Wehrmacht officer. There he temporarily entrusted his incriminating documents to a nurse with whom he had struck up a relationship.[57] He and his unit then hurried west to avoid being captured by the Soviets, but were taken prisoners of war by the Americans in June 1945. Although Mengele was initially registered under his own name, he was not identified as being on the major war criminal list due to the disorganization of the Allies regarding the distribution of wanted lists, and the fact that he did not have the usual SS blood group tattoo.[60] He was released at the end of July and obtained false papers under the name "Fritz Ullman", documents he later altered to read "Fritz Hollmann".[61]