The 15 men present at Wannsee included Adolf Eichmann (head of Jewish affairs for the RSHA and the man who organized the deportation of Jews), Heinrich Müller (head of the Gestapo), and other party leaders and department heads.[256] Thirty copies of the minutes were made. Copy no. 16 was found by American prosecutors in March 1947 in a German Foreign Office folder.[263] Written by Eichmann and stamped "Top Secret", the minutes were written in "euphemistic language" on Heydrich's instructions, according to Eichmann's later testimony.[264] The conference had several purposes. Discussing plans for a "final solution to the Jewish question" ("Endlösung der Judenfrage"), and a "final solution to the Jewish question in Europe" ("Endlösung der europäischen Judenfrage"),[256] it was intended to share information and responsibility, coordinate efforts and policies ("Parallelisierung der Linienführung"), and ensure that authority rested with Heydrich. There was also discussion about whether to include the German Mischlinge (half-Jews).[265] Heydrich told the meeting: "Another possible solution of the problem has now taken the place of emigration, i.e. the evacuation of the Jews to the East, provided that the Fuehrer gives the appropriate approval in advance."[256] He continued:

When an outbreak of noma (a gangrenous bacterial disease of the mouth and face) struck the Romani camp in 1943, Mengele initiated a study to determine the cause of the disease and develop a treatment. He enlisted the assistance of prisoner Dr. Berthold Epstein, a Jewish pediatrician and professor at Prague University. The patients were isolated in a separate barracks and several afflicted children were killed so that their preserved heads and organs could be sent to the SS Medical Academy in Graz and other facilities for study. This research was still ongoing when the Romani camp was liquidated and its remaining occupants killed in 1944.[2]

The conference at Wannsee gave impetus to the so-called second sweep of the Holocaust by the bullet in the east. Between April and July 1942 in Volhynia, 30,000 Jews were murdered in death pits with the help of dozens of newly formed Ukrainian Schutzmannschaft.[67] Owing to good relations with the Ukrainian Hilfsverwaltung,[68] these auxiliary battalions were deployed by the SS also in Russia Center, Russia South, and in Byelorussia; each with about 500 soldiers divided into three companies.[69] They participated in the extermination of 150,000 Volhynian Jews alone, or 98 percent of the Jewish inhabitants of the entire region.[70] In July 1942 the Completion of the Final Solution in the General Government territory which included Distrikt Galizien, was ordered personally by Himmler. He set the initial deadline for 31 December 1942.[71]
In Germany, the Nazis had been murdering mentally and physically disabled people as part of its euthanasia programme since 1939. In the beginning, doctors killed them by lethal injection. This was not considered fast enough, so they developed a new process of gassing that was faster and more effective in killing large numbers of people. Over 70,000 people were killed as part of the euthanasia programme.

…selected by the camp doctor, Josef Mengele, for medical experiments. Auschwitz doctors tested methods of sterilization on the prisoners, using massive doses of radiation, uterine injections, and other barbaric procedures. Experiments involving the killing of twins, upon whom autopsies were performed, were meant to provide information that would supposedly lead…
Genealogical Studies in the Cases of Cleft Lip-Jaw-Palate (1938), his medical dissertation, earned him a doctorate in medicine from Frankfurt University. Studying the influence of genetics as a factor in the occurrence of this deformity, Mengele conducted research on families who exhibited these traits in multiple generations. The work also included notes on other abnormalities found in these family lines.[7][122]

In 1942, with the Nazis occupying Holland, a thirteen-year-old Jewish girl and her family fled their home in Amsterdam and went into hiding. For the next two years, until their whereabouts were betrayed to the Gestapo, the Franks and another family lived cloistered in the “Secret Annexe” of an old office building. Cut off from the outside world, they faced hunger, boredom, the constant cruelties of living in confined quarters, and the ever-present threat of discovery and death. In her diary Anne Frank recorded vivid impressions of her experiences during this period. By turns thoughtful, moving, and surprisingly humorous, her account offers a fascinating commentary on human courage and frailty and a compelling self-portrait of a sensitive and spirited young woman whose promise was tragically cut short.
At Auschwitz-Birkenau, new arrivals were told to carefully hang their clothing on numbered hooks in the undressing room and were instructed to remember the numbers for later. They were given a piece of soap and taken into the adjacent gas chamber disguised as a large shower room. In place of carbon monoxide, pellets of the commercial pesticide Zyklon-B (prussic acid) were poured into openings located above the chamber upon the cynical SS command - Na, gib ihnen shon zu fressen (All right, give 'em something to chew on). The gas pellets fell into hollow shafts made of perforated sheet metal and vaporized upon contact with air, giving off lethal cyanide fumes inside the chamber which oozed out at floor level then rose up toward the ceiling. Children died first since they were closer to the floor. Pandemonium usually erupted as the bitter almond-like odor of the gas spread upwards with adults climbing on top of each other forming a tangled heap of dead bodies all the way up to the ceiling.
German mobile killing squads, called special duty units (Einsatzgruppen), are assigned to kill Jews during the invasion of the Soviet Union. These squads follow the German army as it advances deep into Soviet territory, and carry out mass-murder operations. At first, the mobile killing squads shoot primarily Jewish men. Soon, wherever the mobile killing squads go, they shoot all Jewish men, women, and children, without regard for age or gender. By the spring of 1943, the mobile killing squads will have killed more than a million Jews and tens of thousands of partisans, Roma (Gypsies), and Soviet political officials.
^ Jump up to: a b "Białystok – History". Virtual Shtetl Museum of the History of Polish Jews. p. 6, paragraph #3. According to records, about 5,000 Jews died at that time.[7.2] See: Browning (1998), p. 12 – Weis and his officers subsequently submitted a false report of the events to [General] Pfugbeil ... 2,000 to 2,200 Jews had been killed.[8] – via Internet Archive.

Dr. Mengele had a Ph.D. in Anthropology as well as a degree in medicine, which he received in July 1938 from the University of Frankfurt. He earned his Ph.D. in 1935 with a thesis on "Racial Morphological Research on the Lower Jaw Section of Four Racial Groups." In January 1937, Dr. Mengele was appointed a research assistant at the Institute for Heredity, Biology and Racial Purity at the University of Frankfurt. He worked under Professor Otmar Freiherr von Verschuer, a geneticist who was doing research on twins. As the war-time director of the Kaiser Wilhelm Institute of Anthropology, Human Hereditary Teaching Genetics, located in Berlin, von Verschuer secured the funds for Mengele's experiments at Auschwitz. The results of Mengele's research on twins was sent to this Institute. The grant for Mengele's genetic research was authorized by the German Research Council in August 1943.

According to scholars Christian Gerlach and Peter Monteath, among others, the pivotal moment for Hitler’s decision came on December 12, 1941, at a secret meeting with some 50 Nazi officials, including Joseph Goebbels (Nazi minister of propaganda) and Hans Frank (governor of occupied Poland). Though no written documents of the meeting survive, Goebbels described the meeting in his journal on December 13, 1941:

David Cesarani emphasises the improvised, haphazard nature of Nazi policies in response to changing war time conditions in his overview, Final Solution: The Fate Of The European Jews 1933–49 (2016). "Cesarani provides telling examples", wrote Mark Roseman, "of a lack of coherence and planning for the future in Jewish policy, even when we would most expect it. The classic instance is the invasion of Poland in 1939, when not even the most elementary consideration had been given to what should happen to Poland's Jews either in the shorter or longer term. Given that Poland was home to the largest Jewish population in the world, and that, in a couple of years, it would house the extermination camps, this is remarkable."[118]
In early 1943, encouraged by von Verschuer, Mengele applied to transfer to the concentration camp service.[20][30] His application was accepted and he was posted to Auschwitz, where he was appointed by SS-Standortarzt Eduard Wirths, chief medical officer at Auschwitz, to the position of chief physician of the Zigeunerfamilienlager (Romani family camp) at Birkenau,[20][30] a subcamp located on the main Auschwitz complex. The SS doctors did not administer treatment to the Auschwitz inmates, but supervised the activities of inmate doctors who had been forced to work in the camp medical service.[31] As part of his duties, Mengele made weekly visits to the hospital barracks and ordered any prisoners who had not recovered after two weeks in bed to be sent to the gas chambers.[32]