The orders for the final evacuation and liquidation of the camp were issued in mid-January 1945. The Germans left behind in the main Auschwitz camp, Birkenau and in Monowitz about 7,000 sick or incapacitated who they did not expect would live for long; the rest, approximately 58,000 people, were evacuated by foot into the depths of the Third Reich.
When Anne’s sister, Margot, was faced with deportation (supposedly to a forced-labour camp), the Franks went into hiding on July 6, 1942, in the backroom office and warehouse of Otto Frank’s food-products business. With the aid of a few non-Jewish friends, among them Miep Gies, who smuggled in food and other supplies, the Frank family and four other Jews—Hermann and Auguste van Pels and their son, Peter, and Fritz Pfeffer—lived confined to the “secret annex.” During this time, Anne wrote faithfully in her diary, recounting day-to-day life in hiding, from ordinary annoyances to the fear of capture. She discussed typical adolescent issues as well as her hopes for the future, which included becoming a journalist or a writer. Anne’s last diary entry was written on August 1, 1944. Three days later the annex was discovered by the Gestapo, which was acting on a tip from Dutch informers.

The main camp population grew from 18,000 in December 1942 to 30,000 in March 1943. In July or August 1941, Himmler briefed Höss about the 'Final Solution'. On September 3th, 1941, Soviet POWs at the Auschwitz main camp were used in trials of the poison gas Zyklon-B. This poison gas was produced by the German company "Degesch" (Deutsche Gesellschaft zur Schädlingsbekämpfung). The were gassed in underground cells in Block 11. After this trial, a gas chamber was rigged-up just outside the main camp and in February 1942, two temporary gas chambers opened at Birkenau. The crematories were built by the German company "Topf & son" located at Erfurt.

Yet the question of Anne’s relationship to her Jewishness became a point of controversy between her father and the playwrights and dramatists. The 1955 Broadway play was written by two non-Jewish playwrights, while the play written in 1952 by the Jewish writer Meyer Levin (1905–1981) was rejected because, as the publishers who rejected it told Otto Frank, it was too Jewish, an assessment in which Otto Frank acquiesced. “I always said that … it was not a Jewish book,” he wrote to Levin, “so please do not make it into a Jewish play.” The version written by Albert Hackett and Frances Goodrich was more universal and especially less anti-German than Levin’s; in the United States of the 1950s—the period of the Cold War, the McCarthy era and the fight against the Soviet Union—Communist ideology was the principal enemy and the hostility to Germany of the 1940s was set aside. Several researchers of literature and film believe that the diary, which presented Anne’s character as an impressive human figure who clings to liberal-democratic values, increased the identification of Jews with these universal values, which coincided with the desire of American Jews to be part of the culture of the country that took them in, to assimilate into it, and to emphasize the Holocaust less since it bore out the uniqueness of the Jewish people.
Himmler visited Auschwitz in March 1941 and commanded its enlargement to hold 30,000 prisoners. Himmler also ordered the construction of a second camp for 100,000 inmates on the site of the village of Brzezinka (Birkenau), roughly 4 km from the main camp. This massive camp was intended to be filled with captured Russian POWs who would provide the slave labor to build the SS 'utopia' in Upper Silesia. The chemical giant I G Farben expressed an interest in utilizing this labor force, too. Extensive construction work began in October 1941, under terrible conditions and with massive loss of life. About 10,000 Russian POWs died in the process.
During June and July 1933, all competing parties were either outlawed or dissolved themselves and subsequently the Law against the founding of new parties of 14 July 1933 legally established the Nazi Party's monopoly. On 1 December 1933, the Law to secure the unity of party and state entered into force, which was the base for a progressive intertwining of party structures and state apparatus.[82] By this law, the SA—actually a party division—was given quasi-governmental authority and their leader was co-opted as an ex officio cabinet member. By virtue of a 30 January 1934 Law concerning the reorganisation of the Reich, the Länder (states) lost their statehood and were demoted to administrative divisions of the Reich's government (Gleichschaltung). Effectively, they lost most of their power to the Gaue that were originally just regional divisions of the party, but took over most competencies of the state administration in their respective sectors.[83]
Between 1933 and the fall of Nazi Germany in 1945, more than 3.5 million Germans were forced to spend time in concentration camps and prisons for political reasons,[18][19][20] and approximately 77,000 Germans were executed for one or another form of resistance by Special Courts, courts-martial, and the civil justice system. Many of these Germans had served in government, the military, or in civil positions, which enabled them to engage in subversion and conspiracy against the Nazis.[11]